Ignoring Stross, Isaac fights his way through the city (still filled with survivors trying to escape the Necromorphs) to reach Daina. She also claims that a self-replicating signal was imprinted on Isaac's mind by his previous encounter with the Marker, putting his life in grave danger, which Tiedeman kept in check with memory suppressants. Daina explains that Sprawl administrator Hans Tiedemann is building a new Marker using information encoded in Isaac and Stross' brains. He is also contacted by fellow patient Nolan Stross (a main character from Dead Space: Aftermath), who endured a treatment similar to Isaac's. He is contacted by Daina Le Guin, a woman claiming to have a cure for his "condition". The already-ongoing Necromorph outbreak claims Franco's life, leaving Isaac to escape on his own. Isaac Clarke awakens with no memory of the past three years since Aegis VII, having just been awoken by Franco Delille (protagonist of Dead Space Ignition), who is attempting to free him. The game begins in the asylum on the Sprawl, a densely-populated space station surrounding a shard of Titan, one of Saturn's moons.
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